克里斯托弗医生Hamaker

研究方向和领域

Hamaker组的研究目前主要集中在配位化学,氢键和催化作用。研究项目桥无机和有机化学的传统领域,与接触分析的分析技术。主要有两个项目目前正在调查:(1)配体和过渡金属配合物的合成发展的目标材料对重金属的去除和恢复;(2)分子间相互作用的研究,特别是氢键,在固体(晶体工程);(3)发展不对称催化的新配体。当前项目将允许学生遇到许多合成和分析技术。现代光谱技术包括核磁共振、红外光谱、UV / vis、x射线晶体学,电化学是用来描述新化合物。此外,色谱技术包括GC、GC / MS、薄层色谱、柱色谱法用于识别,量化,催化产品的隔离。项目1:合成新的配体与潜在环境应用程序。重金属是重要的环境污染物。 Mercury is highly toxic and known to bioaccumulate in the food chain, lead can lead to birth defects, and cadmium is acutely toxic. These elements are found in electronic devices and rechargeable batteries. The noble metals Ru, Os, Rh, Ir, Pd, Pt, and Au and their complexes are commonly used as catalysts in the chemical and pharmaceutical industries. Removal of these metals is important not only because of their cost, but also because of their potential toxicity. The recommended limit according to the European Agency for the Evaluation of Medicinal Products for all six of the above listed noble metals combined in active pharmaceutical ingredients (API's) is 5 ppm. Therefore, recovery of these metals is of both environmental and economic importance. Schiff base ligands have been long known, and widely investigated. They are easily synthesized and modified both sterically and electronically. Our research group is currently investigating the coordination chemistry of salicyaldehyde and pyridinecarboxaldehyde imines of methyl carbazate and O-ethyl thiocarbazate with a variety of metals. We have found the chemistry of the O-ethyl thiocarbazate imines to be very similar to the related thiosemicarbazones. The methyl carbazate imines have slightly different chemistry; the pyridylimine derivatives preferring to bind as neutral ligands and the salicylidene derivatives binding as monoanionic ligands . Long term goals include use of the ligands as precipitation agents for heavy metals and covalently attaching these classes of ligands on the surface of materials to generate potentially reusable, heterogeneous systems for the removal of toxic metals. Project 2: Solid state intermolecular interactions (crystal engineering). Intermolecular forces, such as hydrogen bonds and p-stacking, play an important role in both the reactivity and the crystal packing of molecules. Additionally, the physical properties of a substance (including density, color, solubility, etc.) are determined by the intermolecular interactions in the crystalline solid state. Our group is interested in synthesizing simple molecules, such as sulfonamides, with potential hydrogen-bond donor and acceptor groups and examining their solid state structures. We are also investigating the intermolecular interactions of the substituted salicylidenecarbazate ligands, which display interesting intermolecular interactions in the solid state. Project 3: Synthesis of new chiral ligands for asymmetric catalysis. We are interested in preparing chiral ligands for use in asymmetric catalysis