理查德Nagorski

研究方向和领域

领域目前的研究兴趣的面积一般利益在我们集团的机制和反应速率常数是重要的生物分子在水里。一般而言,我们更喜欢观察简单的反应感兴趣的生物分子的分子模拟和扩展我们的观察我们理解的更复杂的生物分子系统的增加。有两个当前利益的领域。首先是稳定常数和专门的调查,carbinolamides的击穿机理。carbinolamides的总体结构方案1所示,和允许各种组织的三种可能的位置替换。我们感兴趣的是这些化合物因为它已经表明carbinolamides酶介导a-amidated肽的合成中间体。然而,很少系统工作的反应carbinolamides已经完成,甚至是不为人熟知的方法促进这些化合物的分解。我们建议研究的反应在水溶液条件下各种carbinolamides和促进其分解的因素。活期利息的第二个领域是酰胺的亲电性,也就是说,酰胺多少负碳离子的亲核攻击。方案2所示是我们感兴趣的一般反应。 The reaction proceeds by the formation of an enolate which can then nucleophilically attack the amide to form 2. Compound 2 will then undergo breakdown to form products. There are many interesting aspects to this reaction, the first of which is the reaction itself. We are familiar with similar reactions of this type (eg. Aldol, Claisen, Dieckmann) but this particular reaction has itself received little or no attention. Secondly, by investigating this reaction we will generate data that will allow us to make conclusions about the electrophilicity of amides that may eventually allow a better understanding of resonance. We propose the study of the mixed-Claisen condensation reaction above to determine the nature of this reaction and gain insight into the electrophilicity of amides. In addition, by changing the R groups on nitrogen we may be able to measure changes in the electrophilicity of the amide. Skills and Techniques of Importance: Students (undergraduate and graduate) who work in my labs will receive a variety of experiences: synthesis and purification of organic compounds learn the proper techniques for the determination and analysis of kinetic data and then put these techniques to use learn the operation of analytical instrumentation for the purposes of isolation and identification of reaction products spectral identification of organic compounds and become familiar with methods of obtaining said spectra